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5 Things To Know About Evusheld

By The National MS Society
January 4, 2022

As we navigate the pandemic together as a community, the Society continues to provide updates regarding COVID-19 vaccines and treatment for people with MS.

The U.S. Food and Drug Administration (FDA) has recently authorized Evusheld for use to prevent COVID-19 in individuals 12 years and older. Here are 5 things we think you should know about Evusheld.

  • Evusheld is used for the prevention of COVID-19

Evusheld can be used for those who are not infected with COVID-19 and have not been recently exposed to someone infected with the virus.

  • Some people with MS qualify for Evusheld

This prevention medication is strictly for those who are not expected to have adequate immune responses to the vaccine or who have a severe allergy to the vaccines.

People with MS who take the following disease modifying therapies may have a reduced or absent immune response to the COVID-19 vaccines and qualify to use Evusheld:

    • Sphingosine 1-phosphate receptor modulators (Gilenya, Mayzent, Zeposia, Ponvory),
    • Alemtuzumab (Lemtrada) treatment within the past 24 months
    • Anti-CD20 monoclonal antibodies (Ocrevus, Kesimpta, Rituxan and biosimilars)
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  • Evusheld is safe to use with MS medications

The treatment can be used alongside disease modifying therapies, although you may need to be coordinate timing with your MS healthcare provider.

  • The Society recommends people with MS get vaccinated

Evusheld is not a vaccine for COVID-19 nor is it a cure for COVID-19. Evusheld is a monoclonal antibody treatment, which delivers human-made antibodies to the body to help fight off infection by attacking the natural spike protein on the surface of the COVID-19 virus. The antibodies last only a few months.

Vaccines work differently by prompting your immune system to “learn” the virus and develop longer-lasting defenses against the virus, which includes producing natural antibodies to the virus.

Getting vaccinated is the best way to slow the spread of the virus and reduce the likelihood of severe symptoms and hospitalization, along with wearing a face mask, physical distancing and washing your hands.

  • You can get vaccinated and get Evusheld

You can get Evusheld at least 2 weeks after the second dose or booster dose of the vaccine.

Your healthcare provider can help determine if Evusheld is right for you. After discussing and coordinating with your healthcare provider, visit the U.S. Department of Health & Human Services website to find a treatment location.


Editor’s Note: Learn more about Evusheld on the Society’s coronavirus resources page.


The National Multiple Sclerosis Society is proud to be a source of information on multiple sclerosis related topics. Unless otherwise indicated, the information provided is based on professional advice, published experience and expert opinion. However, the information does not constitute medical or legal advice. For specific medical advice, consult a qualified physician. For specific legal advice, consult a qualified attorney.

The National MS Society

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